Movie-Film Production Information Summary:

Following the events of the Raccoon City incident in Apocalypse, the T-Virus escaped containment despite the nuclear destruction of the city. The virus then spread from Raccoon City to San Francisco, and the Umbrella Corporation was unable to contain it. The virus quickly spread across the world, drying up the lakes, rivers, and continents while infecting the majority of the human population and spreading to other species. Five years later, The Umbrella Corporation appears to be the only organized society of humans left, its remnants forced to live underground in Hive-like constructs dispersed around the world.

Alice (Milla Jovovich), is now alone in the desert wastelands of the remains of the United States. She has superhuman strength and psionic abilities gained from her brief imprisonment by Umbrella. Umbrella considers re-capturing Alice a top priority because of her blood's ability to bond with the T-Virus. Dr. Sam Isaacs (Iain Glen) believes that he can use blood from the original Alice to develop a permanent cure, as well as tame the undead. Umbrella chairman Albert Wesker (Jason O'Mara) orders Isaacs to create a cure without Alice, using clones created from her blood. Wesker refuses to authorize manpower to recover Alice until they are 100% sure where she is, due to the high risk involved in missions on the surface. The Alice clones endure countless tests within the re-created Spencer Mansion, The Hive, and Raccoon City Hospital locations.